Omaha is considered one of the cities in the Midwest with a high level of healthcare.

Large general hospitals, specialized medical centers, and affiliated hospitals with medical schools are evenly distributed throughout Omaha and its surrounding areas, and patients from across Nebraska, as well as nearby Iowa and South Dakota, often come to Omaha for medical services.

The first representative hospital in Omaha is the Nebraska Medical Center (or The Nebraska Medical Center). This hospital is a university hospital affiliated with the University of Nebraska Medical Center (UNMC) and is the largest general hospital in the Omaha area. It has over 900 beds and provides nationally recognized medical services in various fields, including cancer treatment, cardiology, organ transplantation, and trauma care. Notably, it has isolation treatment facilities for patients with weakened immune systems and was designated as a treatment facility for Ebola patients in 2014, receiving national recognition in the field of special infectious disease treatment. The Fred & Pamela Buffett Cancer Center is located on the UNMC campus, providing comprehensive treatment and research-based medical services for cancer patients in the Omaha area.

The second is the CHI Health Creighton University Medical Center. This hospital, affiliated with Creighton University School of Medicine, is located near downtown Omaha and has a long history of providing extensive medical services to the community. It operates in various specialties, including cardiology, stroke, obstetrics, and pediatrics, and supplies medical services throughout Nebraska and Iowa through the CHI Health system network. Creighton University School of Medicine is one of the leading medical education institutions in the Midwest, and this hospital also serves as a center for medical education and clinical practice.

Thirdly, we cannot overlook the Children's Hospital & Medical Center, a pediatric specialty hospital. Located in Omaha, this hospital is a major institution providing pediatric specialized medical care in Nebraska and Iowa, with over 300 beds. It has high expertise in pediatric cardiology, pediatric oncology, neonatal intensive care, and pediatric emergency medicine, and has gained high trust in the community with its environment and programs that consider both parents and children. This hospital has consistently been listed among the best children's hospitals by US News & World Report.

In addition, Omaha has various hospitals of different sizes, including BryanLGH Medical Center, Methodist Hospital, and Beth Israel Hospital. The healthcare industry in Omaha is a significant part of the city's economy, and medical research and workforce training are actively conducted, centered around UNMC and Creighton University School of Medicine. The number of healthcare professionals in the Omaha area reaches tens of thousands, and the healthcare service industry is a major employment sector that holds a significant share of the overall economy in Omaha.

Omaha's healthcare infrastructure functions not only as a provider of hospital services but also as a center for clinical research and innovative medical technology development. Active research is being conducted in cancer research, infectious disease research, and neuroscience research, centered around UNMC, with ongoing research support from the federal government and private foundations. Notably, the Fred & Pamela Buffett Cancer Center has been designated as a National Cancer Institute (NCI) designated cancer center, officially recognizing Omaha's capabilities in cancer treatment and research at a national level.